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The Effect of Resistance Exercise Intensity on Acute Hyperglycemia in Young Adult Males.

ABSTRACT: The purpose of this study was to examine the effect of resistance exercise (RE) intensity on acute hyperglycemia, in young adult males. Thirteen males (age 23.43 ± 2.18 years, height 175.16 ± 10.44 cm, weight 77.02 ± 8.91 kg, body fat 20 ± 0.03%) participated in three randomized testing sessions, each separated by 96 h. The three testing conditions were: control (CON; induction of hyperglycemia with no-exercise), high (HI; induction of hyperglycemia followed by high-intensity RE: 5 × 4, 90% 1-repetition maximum (1-RM)), and moderate (MO; induction of hyperglycemia followed by low-intensity RE: 3 × 14, 65% 1-RM). In all three testing conditions, participants orally ingested a D100 (100 g/10 oz) glucose beverage at a dosage of 2 g glucose/kg body weight and capillary blood was obtained for plasma glucose and insulin analysis at 0 (fasting), 30, 60, 90 and 120 min, following glucose ingestion. At 30-min post-ingestion in the HI and MO conditions, participants began the respective RE protocols. Acute hyperglycemia was achieved throughout all three 2-h testing conditions; mean 2-h plasma glucose levels during CON (7.1 ± 1.3 mmol?L-1), MO (7.5 ± 0.6 mmol?L-1) and HI (8.2 ± 1.9 mmol?L-1) were all significantly (p < 0.05) greater than mean fasting plasma glucose (5.6 ± 0.46 mmol?L-1). Plasma glucose and insulin did not differ (p < 0.05) between treatment conditions at any times points over the 120 min, however, 2-h glucose area under the curve in the HI condition was significantly greater (p < 0.05) than CON and MO. In conclusion, this study indicates that hyperglycemia, induced prior to RE, may be exacerbated by high-intensity RE.

SUBMITTER: Schick EE

PROVIDER: S-EPMC7552604 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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The Effect of Resistance Exercise Intensity on Acute Hyperglycemia in Young Adult Males.

Schick Evan E EE Segura Luis E LE Emamjomeh Shayán S Cotter Joshua A JA

Sports (Basel, Switzerland) 20200903 9

The purpose of this study was to examine the effect of resistance exercise (RE) intensity on acute hyperglycemia, in young adult males. Thirteen males (age 23.43 ± 2.18 years, height 175.16 ± 10.44 cm, weight 77.02 ± 8.91 kg, body fat 20 ± 0.03%) participated in three randomized testing sessions, each separated by 96 h. The three testing conditions were: control (CON; induction of hyperglycemia with no-exercise), high (HI; induction of hyperglycemia followed by high-intensity RE: 5 × 4, 90% 1-re ...[more]

PMID: 32899107

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Project description:BackgroundPhysical exercise and activity status may modify the effect of the fat mass- and obesity-associated (FTO) genotype on body weight and obesity risk. To understand the interaction between FTO's effect and physical activity, the present study investigated the effects of high and low intensity exercise on FTO mRNA and protein expression, and potential modifiers of exercise-induced changes in FTO in healthy-weighted individuals.MethodsTwenty-eight untrained males and females (25.4?±?1.1?years; 73.1?±?2.0?kg; 178.8?±?1.4?cm; 39.0?±?1.2?ml.kg.min-?1 VO2peak) were genotyped for the FTO rs9939609 (T?>?A) polymorphism and performed isocaloric (400?kcal) cycle ergometer exercise on two separate occasions at different intensities: 80% (High Intensity (HI)) and 40% (Low Intensity (LO)) VO2peak. Skeletal muscle biopsies (vastus lateralis) and blood samples were taken pre-exercise and following 10 and 90 mins passive recovery.ResultsFTO mRNA expression was significantly decreased after HI intensity exercise (p?=?0.003). No differences in basal and post-exercise FTO protein expression were evident between FTO genotypes. Phosphorylated adenosine monophosphate-activated protein kinase (AMPK) and Akt substrate of 160?kDa (AS160) were significantly increased following HI intensity exercise (p?<?0.05). Multivariate models of metabolomic data (orthogonal two partial least squares discriminant analysis (O2PLS-DA)) were unable to detect any significant metabolic differences between genotypes with either exercise trial (p?>?0.05). However, skeletal muscle glucose accumulation at 10 mins following HI (p?=?0.021) and LO (p?=?0.033) intensity exercise was greater in AA genotypes compared to TT genotypes.ConclusionOur novel data provides preliminary evidence regarding the effects of exercise on FTO expression in skeletal muscle. Specifically, high intensity exercise downregulates expression of FTO mRNA and suggests that in addition to nutritional regulation, FTO could also be regulated by exercise.Trial registrationACTRN12612001230842. Registered 21 November 2012 - Prospectively registered, https://www.anzctr.org.au/.

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The Effect of Resistance Exercise Intensity on Acute Hyperglycemia in Young Adult Males.

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The Effect of Resistance Exercise Intensity on Acute Hyperglycemia in Young Adult Males.

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