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Analysis of XX SRY-Negative Sex Reversal Dogs.


ABSTRACT: Impaired fertility associated with disorders of sex development (DSDs) due to genetic causes in dogs are more and more frequently reported. Affected dogs are usually of specific breeds thus representing a cause of economic losses for breeders. The aim of this research is to report the clinical, cytogenetic and molecular genetic findings of four XX SRY-negative DSD dog cases. All the subjects showed a female aspect and the presence of an enlarged clitoris with a penis bone. Morphopathological analyses performed in three of the four cases showed the presence of testes in two cases and ovotestis in another. Conventional and R-banded cytogenetic techniques were applied showing that no chromosome abnormalities were involved in these DSDs. CGH arrays show the presence of 11 copy number variations (CNVs), one of which is a duplication of 458 Kb comprising the genomic region between base 17,503,928 and base 17,962,221 of chromosome 9 (CanFam3 genome assembly). This CNV, confirmed also by qPCR, includes the promoter region of SOX9 gene and could explain the observed phenotype.

SUBMITTER: Albarella S 

PROVIDER: S-EPMC7552623 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Analysis of XX <i>SRY</i>-Negative Sex Reversal Dogs.

Albarella Sara S   Lorenzi Lisa De L   Rossi Elena E   Prisco Francesco F   Riccardi Marita Georgia MG   Restucci Brunella B   Ciotola Francesca F   Parma Pietro P  

Animals : an open access journal from MDPI 20200916 9


Impaired fertility associated with disorders of sex development (DSDs) due to genetic causes in dogs are more and more frequently reported. Affected dogs are usually of specific breeds thus representing a cause of economic losses for breeders. The aim of this research is to report the clinical, cytogenetic and molecular genetic findings of four XX <i>SRY</i>-negative DSD dog cases. All the subjects showed a female aspect and the presence of an enlarged clitoris with a penis bone. Morphopathologi  ...[more]

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