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Additive Biomanufacturing with Collagen Inks.

ABSTRACT: Collagen is a natural polymer found abundantly in the extracellular matrix (ECM). It is easily extracted from a variety of sources and exhibits excellent biological properties such as biocompatibility and weak antigenicity. Additionally, different processes allow control of physical and chemical properties such as mechanical stiffness, viscosity and biodegradability. Moreover, various additive biomanufacturing technology has enabled layer-by-layer construction of complex structures to support biological function. Additive biomanufacturing has expanded the use of collagen biomaterial in various regenerative medicine and disease modelling application (e.g., skin, bone and cornea). Currently, regulatory hurdles in translating collagen biomaterials still remain. Additive biomanufacturing may help to overcome such hurdles commercializing collagen biomaterials and fulfill its potential for biomedicine.

SUBMITTER: Chan WW

PROVIDER: S-EPMC7552643 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Additive Biomanufacturing with Collagen Inks.

Chan Weng Wan WW Yeo David Chen Loong DCL Tan Vernice V Singh Satnam S Choudhury Deepak D Naing May Win MW

Bioengineering (Basel, Switzerland) 20200701 3

Collagen is a natural polymer found abundantly in the extracellular matrix (ECM). It is easily extracted from a variety of sources and exhibits excellent biological properties such as biocompatibility and weak antigenicity. Additionally, different processes allow control of physical and chemical properties such as mechanical stiffness, viscosity and biodegradability. Moreover, various additive biomanufacturing technology has enabled layer-by-layer construction of complex structures to support bi ...[more]

PMID: 32630194

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