Dataset Information

Postoperative anemia is a risk factor for acute kidney injury after open aorta and vena cava surgeries.

ABSTRACT: Open aorta and vena cava surgeries are usually associated with substantial blood loss which may result in postoperative acute kidney injury (AKI). The present study is designed to investigate the prevalence, outcome and risk factors of postoperative AKI associated with open aorta and vena cava surgeries, with a focus on the role of anemia in these conditions. A retrospective review of medical records of Peking Union Medical College Hospital was conducted. Patients who underwent open aorta and vena cava surgeries during January 1, 2010 and June 30, 2014 were included in this study. The primary analysis was between patients underwent open aorta and vena cava surgeryies, with or without postoperative AKI. Multivariable logistic regression models were used to determine risk factors of postoperative AKI. The study included 79 patients (63.3% male) with a mean age of 52.5±17.3 years (range, 17-81 years). Postoperative AKI occurred in 23/79 (29.1%) of the patients. Anemia was present in 11/79 (16%) at baseline, and increased to 45/79 (52%) postoperatively. After adjustment for various risk factors, postoperative anemia (OR, 5.202; 95% CI 1.403-19.285) was independently associated with postoperative AKI. AKI is a common complication in patients who undergo open aorta and vena cava surgeries, and postoperative anemia was the most relevant predictive factor of AKI. Strategies to minimize bleeding and anemia for all patients may be advisable. Further studies are needed to assess the impact of AKI on long term outcome and to examine preventive strategies to address potentially modifiable risk factors.

SUBMITTER: Cui R

PROVIDER: S-EPMC7553320 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Postoperative anemia is a risk factor for acute kidney injury after open aorta and vena cava surgeries.

Cui Rui R Li Fangda F Shao Jiang J Wang Yuzhu Y Yue Cai C Zheng Yuehong Y Li Xuemei X

PloS one 20201013 10

Open aorta and vena cava surgeries are usually associated with substantial blood loss which may result in postoperative acute kidney injury (AKI). The present study is designed to investigate the prevalence, outcome and risk factors of postoperative AKI associated with open aorta and vena cava surgeries, with a focus on the role of anemia in these conditions. A retrospective review of medical records of Peking Union Medical College Hospital was conducted. Patients who underwent open aorta and ve ...[more]

PMID: 33048948

Similar Datasets

Project description:IntroductionPoint-of-care ultrasonography (POCUS) has emerged as an important tool for examining critically ill patients. POCUS devices have become progressively smaller and more accessible, transforming medical practice, and reducing costs. One technological breakthrough was the development of ultraportable scanners with microchip technology, which utilize a probe connected to a smartphone or tablet and incorporate a mobile application that employs artificial intelligence to assist in the interpretation of acquired images. The aim of this study was to compare the accuracy of ultrasound microchip technology with traditional piezoelectric crystal ultrasonography. We analyzed 2 volume status parameters in intensive care unit (ICU) patients with acute kidney injury (AKI) who were receiving kidney replacement therapy (KRT). These parameters were the extravascular pulmonary water, using the lung B-lines; and the inferior vena cava collapsibility index (IVCi).MethodsFifty critically ill patients met the study criteria. Lung POCUS quantified B-lines in 8 quadrants. The IVCi was measured using the maximum and minimum diameters during a respiratory cycle. Both technologies were sequentially employed in a randomized fashion to acquire the parameters at 2 different time points: before the initiation of KRT (T0) and 60 minutes after the procedure had commenced (T60). We calculated the correlation and agreement between the 2 ultrasound scanner modalities.ResultsThe correlation between the 2 technologies for evaluating lung B-lines showed strong positive coefficients, ⍴ = 0.96 and ⍴ = 0.93 at T0 and T60, respectively (P < 0.001 for both). The correlation for IVCi was ρ = 0.70 and ρ = 0.87 at T0 and T60, respectively (P < 0.001 for both). The Bland-Altman plots showed agreement between ultrasound methods for IVCi calculation and B-line quantification. For IVCi calculation at T0, bias was +2.69 (SD: 10.6) (95% confidence interval [CI]: -18.13 to +23.52); at T60, bias was 3.28 (SD: 10.23) (95% CI: -16.77 to +23.34). For B-line quantification, the analysis yielded a bias of -0.3 (SD: 2.73), with a 95% CI of -5.66 to +5.06 at T0; and a bias of 0.2 (SD: 3.23), with a 95% CI of -6.14 to +6.54 at T60.ConclusionOur study observed a good correlation and agreement between microchip and piezoelectric-based ultrasound modalities in evaluating the presence of pulmonary B-lines and inferior vena cava (IVC) dynamics in patients with AKI. Microchip ultrasound, in addition to being portable, user-friendly, and cost-effective, consistently delivers bedside parameters for volume assessment that are comparable to those obtained through POCUS using piezoelectric transducer-based ultrasonography.

Project description:While blood vessels have muscular walls that undergo tonic contractions to alter vascular resistance and, thus, control blood flow, lymphatics at the level of the collecting vessels and higher have muscular walls capable of rapid phasic contractions that generate lymph flow in addition to tonic contractions that regulate lymph flow resistance. While the ability of lymphatics to undergo rapid phasic contractions has been known for several centuries, the biological elements governing this phenomenon remain unknown. In an attempt to gain insight into the structural and regulatory elements that give lymphatic vessels their unique contractile capabilities, we utilized two-color microarray analysis to compare the thoracic duct of the rat to the vena cava of the same donor animal. Total cellular RNA was isolated immediately following vessel isolation and amplified in the presence of amino allyl dUTP. The resulting modified aRNA was conjugated to either Cy3 or Cy5 dye prior to hybridization to a rat 5.7K oligonucleotide array. Analysis and filtering of the data obtained from the microarray image yielded several contractile and regulatory genes with altered expression in the thoracic duct relative to the vena cava. Further evaluation of the data obtained in this study may aid in illustrating the unique properties of the lymphatic vessel and its muscular wall. Keywords: Thoracic duct, lymphatics, microarray Four unique thoracic duct/vena cava sample pairs were individually analyzed via two-color microarray analysis yielding 4 biological replicates. To minimize dye bias, a dye balance design was utilized in which the orientation of dye assignment was alternated between vessel pairs (i.e. two thoracic duct samples were labeled with Cy3 and two were labeled with Cy5). Prior to analysis, the data from 2 of the replicates was transformed to accomodate the dye balance such that all thoracic duct data is interpreted as Cy5 and all vena cava data is interpreted as Cy3.

Dataset Information

Postoperative anemia is a risk factor for acute kidney injury after open aorta and vena cava surgeries.

Publications

Postoperative anemia is a risk factor for acute kidney injury after open aorta and vena cava surgeries.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets