Unknown

Dataset Information

0

Coronary artery calcium testing in low-intermediate risk symptomatic patients with suspected coronary artery disease: An effective gatekeeper to further testing?


ABSTRACT: Computed tomography for quantification of coronary artery calcium (CAC) is a simple non-invasive tool to assess atherosclerotic plaque burden. CAC is highly correlated with coronary atherosclerosis and is a robust predictor of cardiovascular outcomes. Recently, the 2018 ACC/AHA Cholesterol Guidelines endorsed the use of CAC scores in asymptomatic, intermediate risk individuals where the decision to initiate stain therapy is uncertain. However, whether quantification of CAC may play a role in the assessment of symptomatic individuals remains a matter of debate. In this review, we examine the evidence for the use of CAC in low-intermediate risk patients with chest pain. This appraisal places a particular focus on the growing body of literature supporting the negative predictive value of a CAC score of zero to rule out significant coronary artery disease in those without high-risk features. We also evaluate current guidelines, limitations, and future research directions for CAC scoring in this important subgroup of patients.

SUBMITTER: Mahmood T 

PROVIDER: S-EPMC7553353 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

Coronary artery calcium testing in low-intermediate risk symptomatic patients with suspected coronary artery disease: An effective gatekeeper to further testing?

Mahmood Tahir T   Shapiro Michael D MD  

PloS one 20201013 10


Computed tomography for quantification of coronary artery calcium (CAC) is a simple non-invasive tool to assess atherosclerotic plaque burden. CAC is highly correlated with coronary atherosclerosis and is a robust predictor of cardiovascular outcomes. Recently, the 2018 ACC/AHA Cholesterol Guidelines endorsed the use of CAC scores in asymptomatic, intermediate risk individuals where the decision to initiate stain therapy is uncertain. However, whether quantification of CAC may play a role in the  ...[more]

Similar Datasets

| S-EPMC10466200 | biostudies-literature
| S-EPMC10448364 | biostudies-literature
| S-EPMC5536845 | biostudies-literature
| S-EPMC9238474 | biostudies-literature
| S-EPMC7101508 | biostudies-literature
| S-EPMC4879021 | biostudies-literature
| S-EPMC2668594 | biostudies-other
| S-EPMC5422839 | biostudies-literature
| S-EPMC4892993 | biostudies-literature
| S-EPMC10399724 | biostudies-literature