Ontology highlight
ABSTRACT:
SUBMITTER: Huddleston J
PROVIDER: S-EPMC7553778 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
eLife 20200902
Seasonal influenza virus A/H3N2 is a major cause of death globally. Vaccination remains the most effective preventative. Rapid mutation of hemagglutinin allows viruses to escape adaptive immunity. This antigenic drift necessitates regular vaccine updates. Effective vaccine strains need to represent H3N2 populations circulating one year after strain selection. Experts select strains based on experimental measurements of antigenic drift and predictions made by models from hemagglutinin sequences. ...[more]