Ontology highlight
ABSTRACT:
SUBMITTER: Hong KU
PROVIDER: S-EPMC7553889 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Hong Kyung U KU Doll Mark A MA Lykoudi Angeliki A Salazar-González Raúl A RA Habil Mariam R MR Walls Kennedy M KM Bakr Alaa F AF Ghare Smita S SS Barve Shirish S SS Arteel Gavin E GE Hein David W DW
Toxicology reports 20200928
Recent reports suggest that arylamine <i>N</i>-acetyltransferases (NAT1 and/or NAT2) serve important roles in regulation of energy utility and insulin sensitivity. We investigated the interaction between diet (control vs. high-fat diet) and acetylator phenotype (rapid vs. slow) using previously established congenic rat lines (in F344 background) that exhibit rapid or slow Nat2 (orthologous to human NAT1) acetylator genotypes. Male and female rats of each genotype were fed control or high-fat (We ...[more]