Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC7554153 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Wang Boxiao B Thurmond Stephanie S Zhou Kang K Sánchez-Aparicio Maria T MT Fang Jian J Lu Jiuwei J Gao Linfeng L Ren Wendan W Cui Yanxiang Y Veit Ethan C EC Hong HeaJin H Evans Matthew J MJ O'Leary Seán E SE García-Sastre Adolfo A Zhou Z Hong ZH Hai Rong R Song Jikui J
Nature structural & molecular biology 20200810 10
Suppressing cellular signal transducers of transcription 2 (STAT2) is a common strategy that viruses use to establish infections, yet the detailed mechanism remains elusive, owing to a lack of structural information about the viral-cellular complex involved. Here, we report the cryo-EM and crystal structures of human STAT2 (hSTAT2) in complex with the non-structural protein 5 (NS5) of Zika virus (ZIKV) and dengue virus (DENV), revealing two-pronged interactions between NS5 and hSTAT2. First, the ...[more]