A pathoconnectome of early neurodegeneration: Network changes in retinal degeneration.

ABSTRACT: Connectomics has demonstrated that synaptic networks and their topologies are precise and directly correlate with physiology and behavior. The next extension of connectomics is pathoconnectomics: to map neural network synaptology and circuit topologies corrupted by neurological disease in order to identify robust targets for therapeutics. In this report, we characterize a pathoconnectome of early retinal degeneration. This pathoconnectome was generated using serial section transmission electron microscopy to achieve an ultrastructural connectome with 2.18nm/px resolution for accurate identification of all chemical and gap junctional synapses. We observe aberrant connectivity in the rod-network pathway and novel synaptic connections deriving from neurite sprouting. These observations reveal

SUBMITTER: Pfeiffer RL 

PROVIDER: S-EPMC7554222 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature