Ontology highlight
ABSTRACT:
SUBMITTER: Juhl DW
PROVIDER: S-EPMC7554302 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Juhl Dennis Wilkens DW Glattard Elise E Lointier Morane M Bampilis Panos P Bechinger Burkhard B
Frontiers in cellular and infection microbiology 20200930
Magainin 2 and PGLa are antimicrobial peptides found together in frog skin secretions. When added as a mixture they show an order of magnitude increase in antibacterial activity and in model membrane permeation assays. Here we demonstrate that both peptides can form fibers with beta-sheet/turn signature in ATR-FTIR- and CD-spectroscopic analyses, but with different morphologies in EM images. Whereas, fiber formation results in acute reduction of the antimicrobial activity of the individual pepti ...[more]