Dataset Information

IRhom2: An Emerging Adaptor Regulating Immunity and Disease.

ABSTRACT: The rhomboid family are evolutionary conserved intramembrane proteases. Their inactive members, iRhom in Drosophila melanogaster and iRhom1 and iRhom2 in mammals, lack the catalytic center and are hence labelled "inactive" rhomboid family members. In mammals, both iRhoms are involved in maturation and trafficking of the ubiquitous transmembrane protease a disintegrin and metalloprotease (ADAM) 17, which through cleaving many biologically active molecules has a critical role in tumor necrosis factor alpha (TNF?), epidermal growth factor receptor (EGFR), interleukin-6 (IL-6) and Notch signaling. Accordingly, with iRhom2 having a profound influence on ADAM17 activation and substrate specificity it regulates these signaling pathways. Moreover, iRhom2 has a role in the innate immune response to both RNA and DNA viruses and in regulation of keratin subtype expression in wound healing and cancer. Here we review the role of iRhom2 in immunity and disease, both dependent and independent of its regulation of ADAM17.

SUBMITTER: Al-Salihi MA

PROVIDER: S-EPMC7554728 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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iRhom2: An Emerging Adaptor Regulating Immunity and Disease.

Al-Salihi Mazin A MA Lang Philipp A PA

International journal of molecular sciences 20200908 18

The rhomboid family are evolutionary conserved intramembrane proteases. Their inactive members, iRhom in <i>Drosophila melanogaster</i> and iRhom1 and iRhom2 in mammals, lack the catalytic center and are hence labelled "inactive" rhomboid family members. In mammals, both iRhoms are involved in maturation and trafficking of the ubiquitous transmembrane protease a disintegrin and metalloprotease (ADAM) 17, which through cleaving many biologically active molecules has a critical role in tumor necro ...[more]

PMID: 32911849

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Dataset Information

IRhom2: An Emerging Adaptor Regulating Immunity and Disease.

Publications

iRhom2: An Emerging Adaptor Regulating Immunity and Disease.

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