Characterization of a Topically Testable Model of Burn Injury on Human Skin Explants.

ABSTRACT: Severe burn injuries remain a major health problem due to high rates of mortality, residual morbidity, and/or aesthetic damages. To find new therapies aimed at promoting a harmonious healing of skin burns, it is important to develop models which take into account the unique properties of the human skin. Based on previously described models of burn injury performed on human skin explants, we hypothesized that maintaining explants under constant tension forces would allow to more closely reproduce the pathophysiological processes of skin remodeling. We thus. Here, we set up and characterized an improved model of deep second-degree burn injury on ex vivo cultured human skin explants at air-liquid interface and maintained under conditions of constant tension forces. A spontaneous re-epithelial

SUBMITTER: Gross-Amat O 

PROVIDER: S-EPMC7554828 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature