Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance?
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ABSTRACT:
SUBMITTER: Genders AJ
PROVIDER: S-EPMC7554894 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance?
Genders Amanda J AJ Holloway Graham P GP Bishop David J DJ
International journal of molecular sciences 20200922 18
As a major site of glucose uptake following a meal, skeletal muscle has an important role in whole-body glucose metabolism. Evidence in humans and animal models of insulin resistance and type 2 diabetes suggests that alterations in mitochondrial characteristics accompany the development of skeletal muscle insulin resistance. However, it is unclear whether changes in mitochondrial content, respiratory function, or substrate oxidation are central to the development of insulin resistance or occur i ...[more]
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