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An Update on Vitamin D Metabolism.


ABSTRACT: Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1?-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review. Moreover, in the last decades, several extraskeletal effects which can be attributed to vitamin D have been shown. These beneficial effects will be here summarized, focusing on the immune system and cardiovascular system.

SUBMITTER: Saponaro F 

PROVIDER: S-EPMC7554947 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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An Update on Vitamin D Metabolism.

Saponaro Federica F   Saba Alessandro A   Zucchi Riccardo R  

International journal of molecular sciences 20200908 18


Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1α-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review. Moreover, in the last decades, severa  ...[more]

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