Ontology highlight
ABSTRACT:
SUBMITTER: Lin CW
PROVIDER: S-EPMC7555415 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Lin Cheng-Wen CW Bai Li-Yuan LY Su Jui-Hsin JH Chiu Chang-Fang CF Lin Wei-Yu WY Huang Wei-Ting WT Shih Ming-Cheng MC Huang Yu-Ting YT Hu Jing-Lan JL Weng Jing-Ru JR
Biomedicines 20200820 9
In this study, the anti-tumor activity of ilimaquinone (IQ), a sesquiterpene quinone isolated from marine sponge <i>Halichondria</i> sp., in oral squamous cell carcinoma (OSCC) cells, was investigated. IQ suppressed the viability of the OSCC cell lines SCC4 and SCC2095 with IC<sub>50</sub> values of 7.5 and 8.5 μM, respectively. Flow cytometric analysis demonstrated that IQ induced caspase-dependent apoptosis in SCC4 cells and modulated the expression of several cell growth-related gene products ...[more]