Ontology highlight
ABSTRACT:
SUBMITTER: Easter M
PROVIDER: S-EPMC7555616 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Easter Molly M Bollenbecker Seth S Barnes Jarrod W JW Krick Stefanie S
International journal of molecular sciences 20200921 18
Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the third leading cause of death worldwide. COPD is characterized by chronic airway inflammation, loss of alveolar-capillary units, and progressive decline in lung function. Major risk factors for COPD are cigarette smoking and aging. COPD-associated pathomechanisms include multiple aging pathways such as telomere attrition, epigenetic alterations, altered nutrient sensing, mitochondrial dysfunction, cell senescence ...[more]