The Role of Smoothened in Cancer.
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ABSTRACT:
SUBMITTER: Jeng KS
PROVIDER: S-EPMC7555769 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
The Role of Smoothened in Cancer.
Jeng Kuo-Shyang KS Sheen I-Shyan IS Leu Chuen-Miin CM Tseng Ping-Hui PH Chang Chiung-Fang CF
International journal of molecular sciences 20200918 18
Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway involves the activation of SMO or GLI through other pathways. The role of SMO has been discussed in different types of cancer, including breast, li ...[more]
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