Ontology highlight
ABSTRACT:
SUBMITTER: Luque Paz D
PROVIDER: S-EPMC7556129 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Luque Paz Damien D Jouanneau-Courville Rébecca R Riou Jérémie J Ianotto Jean-Christophe JC Boyer Françoise F Chauveau Aurélie A Renard Maxime M Chomel Jean-Claude JC Cayssials Emilie E Gallego-Hernanz Maria-Pilar MP Pastoret Cédric C Murati Anne A Courtier Frédéric F Rousselet Marie-Christine MC Quintin-Roué Isabelle I Cottin Laurane L Orvain Corentin C Thépot Sylvain S Chrétien Jean-Marie JM Delneste Yves Y Ifrah Norbert N Blanchet Odile O Hunault-Berger Mathilde M Lippert Eric E Ugo Valérie V
Blood advances 20201001 19
Among myeloproliferative neoplasms, polycythemia vera (PV) and essential thrombocythemia (ET) are the 2 entities associated with the most chronic disease course. Leukemic evolution occurs rarely but has a grim prognosis. The interval between diagnosis and leukemic evolution is highly variable, from a few years to >20 years. We performed a molecular evaluation of 49 leukemic transformations of PV and ET by targeted next-generation sequencing. Using a hierarchical classification, we identified 3 m ...[more]