Gut microbiota from androgen-altered donors alter pulmonary responses to ozone in female mice.
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ABSTRACT:
SUBMITTER: Osgood RS
PROVIDER: S-EPMC7556311 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Gut microbiota from androgen-altered donors alter pulmonary responses to ozone in female mice.
Osgood Ross S RS Tashiro Hiroki H Kasahara David I DI Yeliseyev Vladimir V Bry Lynn L Shore Stephanie A SA
Physiological reports 20201001 19
In mice, both androgens and the gut microbiota modify pulmonary responses to ozone. We hypothesized that androgens affect gut microbiota and thereby impact pulmonary responses to ozone. To address this hypothesis, we transferred cecal microbiota from male castrated or sham castrated C57BL/6J mice into female germ-free recipient C57BL/6J mice. Four weeks later mice were exposed to ozone (2 ppm) or room air for 3 hr. The gut microbiomes of castrated versus sham castrated donors differed, as did th ...[more]
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