Ontology highlight
ABSTRACT:
SUBMITTER: Angelidou A
PROVIDER: S-EPMC7556328 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Angelidou Asimenia A Conti Maria-Giulia MG Diray-Arce Joann J Benn Christine S CS Shann Frank F Netea Mihai G MG Liu Mark M Potluri Lakshmi Prasad LP Sanchez-Schmitz Guzman G Husson Robert R Ozonoff Al A Kampmann Beate B van Haren Simon Daniël SD Levy Ofer O
Vaccine 20200128 9
<h4>Background</h4>Bacille Calmette-Guérin (BCG), the live attenuated tuberculosis vaccine, is manufactured under different conditions across the globe generating formulations that may differ in clinical efficacy. Innate immune recognition of live BCG contributes to immunogenicity suggesting that differences in BCG viability may contribute to divergent activity of licensed formulations.<h4>Methods</h4>We compared BCG-Denmark (DEN), -Japan (JPN), -India (IND), -Bulgaria (BUL) and -USA in vitro wi ...[more]