Ontology highlight
ABSTRACT:
SUBMITTER: Cui X
PROVIDER: S-EPMC7556869 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Cui Xin X Ma Chao C Vasudevaraja Varshini V Serrano Jonathan J Tong Jie J Peng Yansong Y Delorenzo Michael M Shen Guomiao G Frenster Joshua J Morales Renee-Tyler Tan RT Qian Weiyi W Tsirigos Aristotelis A Chi Andrew S AS Jain Rajan R Kurz Sylvia C SC Sulman Erik P EP Placantonakis Dimitris G DG Snuderl Matija M Chen Weiqiang W
eLife 20200910
Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity and immunosuppressive tumor microenvironments. Here, we report a microfluidics-based, patient-specific 'GBM-on-a-Chip' microphysiological system to dissect the heterogeneity of immunosuppressive tumor microenvironments and optimize anti-PD-1 immunotherapy for different GBM subtypes. Our clinical and experimental analyses demonstrated that ...[more]