Ontology highlight
ABSTRACT:
SUBMITTER: Hebbar S
PROVIDER: S-EPMC7557679 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Hebbar Sarita S Schuhmann Kai K Shevchenko Andrej A Knust Elisabeth E
The Journal of cell biology 20201201 12
Apical domains of epithelial cells often undergo dramatic changes during morphogenesis to form specialized structures, such as microvilli. Here, we addressed the role of lipids during morphogenesis of the rhabdomere, the microvilli-based photosensitive organelle of Drosophila photoreceptor cells. Shotgun lipidomics analysis performed on mutant alleles of the polarity regulator crumbs, exhibiting varying rhabdomeric growth defects, revealed a correlation between increased abundance of hydroxylate ...[more]