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Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors.

ABSTRACT: Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being developed to improve therapy and diagnosis, as well as to produce inhibitory drugs and biosensors for a rapid, minimally invasive, and effective detection. In this regard, even more efficient cytokine receptors are under investigation. In this paper we analyze a set of IL-6 cytokine receptors, investigating their topological features by means of a theoretical approach. Our results suggest a topological indicator that may help in the identification of those receptors having the highest complementarity with the protein, a feature expected to ensure a stable binding. Furthermore, we propose and discuss the use of these receptors in an idealized experimental setup.

SUBMITTER: Alfinito E

PROVIDER: S-EPMC7557795 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors.

Alfinito Eleonora E Beccaria Matteo M Ciccarese Mariangela M

Biosensors 20200824 9

Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being developed to improve therapy and diagnosis, as well as to produce inhibitory drugs and biosensors for a rapid, minimally invasive, and effective detection. In this regard, even more efficient cytokine receptors are under investigation. In this paper w ...[more]

PMID: 32847008

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