Ontology highlight
ABSTRACT:
SUBMITTER: Malebari AM
PROVIDER: S-EPMC7558282 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Malebari Azizah M AM Ibrahim Tarek S TS Salem Ibrahim M IM Salama Ismail I Khayyat Ahdab N AN Mostafa Samia M SM El-Sabbagh Osama I OI Darwish Khaled M KM
Pharmaceuticals (Basel, Switzerland) 20200918 9
The membrane-bound human carbonic anhydrase (hCA) IX is widely recognized as a marker of tumor hypoxia and a prognostic factor within several human cancers. Being undetected in most normal tissues, hCA-IX implies the pharmacotherapeutic advent of reduced off-target adverse effects. We assessed the potential anticancer activity of bumetanide-based analogues to inhibit the hCA-IX enzymatic activity and cell proliferation of two solid cancer cell lines, namely kidney carcinoma (A-498) and bladder s ...[more]