Dataset Information

Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway.

ABSTRACT:

Background

Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined.

Methods

Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry analysis of both childhood trauma and body mass index (BMI) was performed in the longitudinal IMAGEN cohort; validation of the findings was performed in the UKB. White-matter connectivity analysis was conducted to study the structural connectivity between the identified brain region and subdivisions of the hypothalamus in the HCP.

Results

In IMAGEN, a smaller frontopolar cortex (FPC) was associated with both childhood abuse (CA) (β = - .568, 95%CI - .942 to - .194; p = .003) and higher BMI (β = - .086, 95%CI - .128 to - .043; p < .001) in male participants, and these findings were validated in UKB. Across seven data collection sites, a stronger negative CA-FPC association was correlated with a higher positive CA-BMI association (β = - 1.033, 95%CI - 1.762 to - .305; p = .015). Using 7-T diffusion tensor imaging data (n = 156), we found that FPC was the third most connected cortical area with the hypothalamus, especially the lateral hypothalamus. A smaller FPC at age 14 contributed to higher BMI at age 19 in those male participants with a history of CA, and the CA-FPC interaction enabled a model at age 14 to account for some future weight gain during a 5-year follow-up (variance explained 5.8%).

Conclusions

The findings highlight that a malfunctioning, top-down cognitive or behavioral control system, independent of genetic predisposition, putatively contributes to excessive weight gain in a particularly vulnerable population, and may inform treatment approaches.

SUBMITTER: Luo Q

PROVIDER: S-EPMC7559717 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway.

Luo Qiang Q Zhang Lingli L Huang Chu-Chung CC Zheng Yan Y Kanen Jonathan W JW Zhao Qi Q Yao Ye Y Quinlan Erin B EB Jia Tianye T Banaschewski Tobias T Bokde Arun L W ALW Bromberg Uli U Büchel Christian C Flor Herta H Frouin Vincent V Garavan Hugh H Gowland Penny P Heinz Andreas A Ittermann Bernd B Martinot Jean-Luc JL Martinot Marie-Laure Paillère MP Nees Frauke F Orfanos Dimitri Papadopoulos DP Poustka Luise L Hohmann Sarah S Fröhner Juliane H JH Smolka Michael N MN Walter Henrik H Whelan Robert R Sahakian Barbara J BJ Schumann Gunter G Li Fei F Feng Jianfeng J Desrivières Sylvane S Robbins Trevor W TW

BMC medicine 20201015 1

<h4>Background</h4>Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined.<h4>Methods</h4>Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry analysis of both childhood trauma and body mass index (BMI) was performed in the longitudinal IMAGEN cohort; validation of the find ...[more]

PMID: 33054810

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Dataset Information

Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway.

Background

Methods

Results

Conclusions

Publications

Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway.

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