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Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway.


ABSTRACT: BACKGROUND:Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined. METHODS:Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry analysis of both childhood trauma and body mass index (BMI) was performed in the longitudinal IMAGEN cohort; validation of the findings was performed in the UKB. White-matter connectivity analysis was conducted to study the structural connectivity between the identified brain region and subdivisions of the hypothalamus in the HCP. RESULTS:In IMAGEN, a smaller frontopolar cortex (FPC) was associated with both childhood abuse (CA) (??=?-?.568, 95%CI -?.942 to -?.194; p?=?.003) and higher BMI (??=?-?.086, 95%CI -?.128 to -?.043; p?

SUBMITTER: Luo Q 

PROVIDER: S-EPMC7559717 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway.

Luo Qiang Q   Zhang Lingli L   Huang Chu-Chung CC   Zheng Yan Y   Kanen Jonathan W JW   Zhao Qi Q   Yao Ye Y   Quinlan Erin B EB   Jia Tianye T   Banaschewski Tobias T   Bokde Arun L W ALW   Bromberg Uli U   Büchel Christian C   Flor Herta H   Frouin Vincent V   Garavan Hugh H   Gowland Penny P   Heinz Andreas A   Ittermann Bernd B   Martinot Jean-Luc JL   Martinot Marie-Laure Paillère MP   Nees Frauke F   Orfanos Dimitri Papadopoulos DP   Poustka Luise L   Hohmann Sarah S   Fröhner Juliane H JH   Smolka Michael N MN   Walter Henrik H   Whelan Robert R   Sahakian Barbara J BJ   Schumann Gunter G   Li Fei F   Feng Jianfeng J   Desrivières Sylvane S   Robbins Trevor W TW  

BMC medicine 20201015 1


<h4>Background</h4>Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined.<h4>Methods</h4>Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry analysis of both childhood trauma and body mass index (BMI) was performed in the longitudinal IMAGEN cohort; validation of the find  ...[more]

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