Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC7559774 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance.
Zhang Yue Y Qian Huizhu H He Jing J Gao Wen W
Biomarker research 20201015
The tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are newly discovered noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre-tRNAs and expressed in various cancers. They enhance cell proliferation and metastasis or inhibit cancer progression. Many studies have investigated their roles in the diagnosis, progression, metastasis, and prognosis of various cancers, but the mechanisms through which they are involved in resistance to cancer treatment are unc ...[more]
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