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Rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis-a possible interface?

ABSTRACT: BACKGROUND:Rheumatoid arthritis (RA) and periodontitis (PD) are proven to share common risk markers, including genetic factors. In the present study we focused on genetic variants in PTPN22 (rs2476601), PADI4 (rs2240340), CTLA4 genes (rs3087243) and its impact on RA and PD. MATERIALS AND METHODS:In the study 111 RA patients and 256 systemically healthy controls were involved. A subdivision of patients and controls was carried out according the severity of periodontitis (no/level 1 PD vs. level 2 PD). RESULTS:I. Evaluating the genetic impact on the occurrence of RA the T allele of rs2476601 (PTPN22) (bivariate: p?

SUBMITTER: Schulz S

PROVIDER: S-EPMC7559817 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis-a possible interface?

Schulz Susanne S Zimmer Pauline P Pütz Natalie N Jurianz Elisa E Schaller Hans-Günter HG Reichert Stefan S

Journal of translational medicine 20201015 1

<h4>Background</h4>Rheumatoid arthritis (RA) and periodontitis (PD) are proven to share common risk markers, including genetic factors. In the present study we focused on genetic variants in PTPN22 (rs2476601), PADI4 (rs2240340), CTLA4 genes (rs3087243) and its impact on RA and PD.<h4>Materials and methods</h4>In the study 111 RA patients and 256 systemically healthy controls were involved. A subdivision of patients and controls was carried out according the severity of periodontitis (no/level 1 ...[more]

PMID: 33059697

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