Ontology highlight
ABSTRACT:
SUBMITTER: Bordignon S
PROVIDER: S-EPMC7559828 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Bordignon Simone S Cerreia Vioglio Paolo P Amadio Elena E Rossi Federica F Priola Emanuele E Voinovich Dario D Gobetto Roberto R Chierotti Michele R MR
Pharmaceutics 20200828 9
We report on the preparation, characterization, and bioavailability properties of three new crystal forms of ethionamide, an antitubercular agent used in the treatment of drug-resistant tuberculosis. The new adducts were obtained by combining the active pharmaceutical ingredient with three dicarboxylic acids, namely glutaric, malonic and tartaric acid, in equimolar ratios. Crystal structures were obtained for all three adducts and were compared with two previously reported multicomponent systems ...[more]