Multi-time-point data preparation robustly reveals MCI and dementia risk factors.
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ABSTRACT:
SUBMITTER: Kaur D
PROVIDER: S-EPMC7560502 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Multi-time-point data preparation robustly reveals MCI and dementia risk factors.
Kaur Daman D Bucholc Magda M Finn David P DP Todd Stephen S Wong-Lin KongFatt K McClean Paula L PL
Alzheimer's & dementia (Amsterdam, Netherlands) 20201014 1
<h4>Introduction</h4>Conflicting results on dementia risk factors have been reported across studies. We hypothesize that variation in data preparation methods may partially contribute to this issue.<h4>Methods</h4>We propose a comprehensive data preparation approach comparing individuals with stable diagnosis over time to those who progress to mild cognitive impairment (MCI)/dementia. This was compared to the often-used "baseline" analysis. Multivariate logistic regression was used to evaluate b ...[more]
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