Ontology highlight
ABSTRACT:
SUBMITTER: Cui A
PROVIDER: S-EPMC7560521 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Cui Anfang A Xue Yuchan Y Wang Xi'ao X Huang Yanhong Y Han Xiaolin X Li Xiangling X Niu Delei D Niu Shaorui S Zhao Yujie Y Yang Xinyu X Yu Wei W
Bioscience reports 20201001 10
Non-small cell lung cancer (NSCLC) is one of the most common causes of cancer-related mortality globally. However, the mechanism underlying NSCLC is not fully understood. Here, we investigated the role of cancer-related regulator of actin dynamics (CRAD) in NSCLC. We showed that CRAD was up-regulated in human NSCLC tissues and lung cancer cell lines. Lentivirus-mediated knockdown of CRAD repressed the proliferation and colony growth of A549 and H1299 cells. Apoptosis was enhanced by CRAD silenci ...[more]