Ontology highlight
ABSTRACT:
SUBMITTER: Brady SW
PROVIDER: S-EPMC7560655 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Brady Samuel W SW Liu Yanling Y Ma Xiaotu X Gout Alexander M AM Hagiwara Kohei K Zhou Xin X Wang Jian J Macias Michael M Chen Xiaolong X Easton John J Mulder Heather L HL Rusch Michael M Wang Lu L Nakitandwe Joy J Lei Shaohua S Davis Eric M EM Naranjo Arlene A Cheng Cheng C Maris John M JM Downing James R JR Cheung Nai-Kong V NV Hogarty Michael D MD Dyer Michael A MA Zhang Jinghui J
Nature communications 20201014 1
Neuroblastoma is a pediatric malignancy with heterogeneous clinical outcomes. To better understand neuroblastoma pathogenesis, here we analyze whole-genome, whole-exome and/or transcriptome data from 702 neuroblastoma samples. Forty percent of samples harbor at least one recurrent driver gene alteration and most aberrations, including MYCN, ATRX, and TERT alterations, differ in frequency by age. MYCN alterations occur at median 2.3 years of age, TERT at 3.8 years, and ATRX at 5.6 years. COSMIC m ...[more]