Ontology highlight
ABSTRACT:
SUBMITTER: Burke L
PROVIDER: S-EPMC7560826 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Burke Lynsey L Guterman Inna I Palacios Gallego Raquel R Britton Robert G RG Burschowsky Daniel D Tufarelli Cristina C Rufini Alessandro A
Cell death discovery 20201014
The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread. Pyrroline-5-carboxylate reductase (PYCR) and proline dehydrogenase (PRODH) enzymes, which catalyze the last step in proline biosynthesis and the first step of its catabolism, respectively, have been extensively associated with the progression of several malignancies, and have been exposed as potential targets for ...[more]