Ontology highlight
ABSTRACT:
SUBMITTER: Block MS
PROVIDER: S-EPMC7560895 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Block Matthew S MS Dietz Allan B AB Gustafson Michael P MP Kalli Kimberly R KR Erskine Courtney L CL Youssef Bahaaeldin B Vijay Geraldine V GV Allred Jacob B JB Pavelko Kevin D KD Strausbauch Michael A MA Lin Yi Y Grudem Megan E ME Jatoi Aminah A Klampe Carolyn M CM Wahner-Hendrickson Andrea E AE Weroha S John SJ Glaser Gretchen E GE Kumar Amanika A Langstraat Carrie L CL Solseth Mary L ML Deeds Michael C MC Knutson Keith L KL Cannon Martin J MJ
Nature communications 20201014 1
In ovarian cancer (OC), IL-17-producing T cells (Th17s) predict improved survival, whereas regulatory T cells predict poorer survival. We previously developed a vaccine whereby patient-derived dendritic cells (DCs) are programmed to induce Th17 responses to the OC antigen folate receptor alpha (FRα). Here we report the results of a single-arm open-label phase I clinical trial designed to determine vaccine safety and tolerability (primary outcomes) and recurrence-free survival (secondary outcome) ...[more]