Anti-adipogenic effect of Lactobacillus fermentum MG4231 and MG4244 through AMPK pathway in 3T3-L1 preadipocytes.
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ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC7561660 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Anti-adipogenic effect of <i>Lactobacillus fermentum</i> MG4231 and MG4244 through AMPK pathway in 3T3-L1 preadipocytes.
Kim SukJin S Choi Soo-Im SI Jang Miran M Jeong Yulah Y Kang Chang-Ho CH Kim Gun-Hee GH
Food science and biotechnology 20201006 11
This study evaluated the anti-adipogenic effects and mechanisms underlying the action of <i>Lactobacillus fermentum</i> MG4231 and MG4244 strains on adipogenesis and lipid accumulation in 3T3-L1 preadipocytes. Treatment with cell-free extracts (CFEs) from the two strains reduced lipid accumulation and intracellular triglyceride production in 3T3-L1 adipocytes by more than 50%. The inhibitory effects of <i>L. fermentum</i> on lipid accumulation were mediated by the downregulation of FAS and aP2 r ...[more]
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