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Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer.


ABSTRACT: Comprehensive serum glycopeptide spectra analysis (CSGSA) evaluates >10,000 serum glycopeptides and identifies unique glycopeptide peaks and patterns via supervised orthogonal partial least-squares discriminant modeling. CSGSA was more accurate than cancer antigen 125 (CA125) or human epididymis protein 4 (HE4) for detecting early stage epithelial ovarian cancer. Combined CSGSA, CA125, and HE4 had improved diagnostic performance. Thus, CSGSA may be a useful screening tool for detecting early stage epithelial ovarian cancer.

SUBMITTER: Matsuo K 

PROVIDER: S-EPMC7563232 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer.

Matsuo Koji K   Tanabe Kazuhiro K   Hayashi Masaru M   Ikeda Masae M   Yasaka Miwa M   Machida Hiroko H   Shida Masako M   Sato Kenji K   Yoshida Hiroshi H   Hirasawa Takeshi T   Imanishi Tadashi T   Mikami Mikio M  

Cancers 20200821 9


Comprehensive serum glycopeptide spectra analysis (CSGSA) evaluates >10,000 serum glycopeptides and identifies unique glycopeptide peaks and patterns via supervised orthogonal partial least-squares discriminant modeling. CSGSA was more accurate than cancer antigen 125 (CA125) or human epididymis protein 4 (HE4) for detecting early stage epithelial ovarian cancer. Combined CSGSA, CA125, and HE4 had improved diagnostic performance. Thus, CSGSA may be a useful screening tool for detecting early sta  ...[more]

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