Ontology highlight
ABSTRACT:
SUBMITTER: Ma M
PROVIDER: S-EPMC7563248 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Ma Mengnan M Zhang Jinbi J Gao Xiaomeng X Yao Wang W Li Qifa Q Pan Zengxiang Z
Biomolecules 20200904 9
Follicular atresia is an inevitable degenerative process that occurs in mammalian ovarian follicles. The molecular events involved in atresia, particularly granulosa cell apoptosis, have long attracted researchers' attention. Vascular endothelial growth factor A (VEGFA) is downregulated during follicular atresia in porcine ovaries and serves as an inhibitor of apoptosis in granulosa cells. In addition, transforming growth factor (TGF)-βsignaling has been considered a central trigger in granulosa ...[more]