Targeting Receptors on Cancer Cells with Protein Toxins.
Ontology highlight
ABSTRACT:
SUBMITTER: Antignani A
PROVIDER: S-EPMC7563326 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Targeting Receptors on Cancer Cells with Protein Toxins.
Antignani Antonella A Ho Eric Chun Hei ECH Bilotta Maria Teresa MT Qiu Rong R Sarnvosky Robert R FitzGerald David J DJ
Biomolecules 20200917 9
Cancer cells frequently upregulate surface receptors that promote growth and survival. These receptors constitute valid targets for intervention. One strategy involves the delivery of toxic payloads with the goal of killing those cancer cells with high receptor levels. Delivery can be accomplished by attaching a toxic payload to either a receptor-binding antibody or a receptor-binding ligand. Generally, the cell-binding domain of the toxin is replaced with a ligand or antibody that dictates a ne ...[more]
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