Ontology highlight
ABSTRACT:
SUBMITTER: Singh SK
PROVIDER: S-EPMC7563377 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Singh Santosh Kumar SK Gordetsky Jennifer B JB Bae Sejong S Acosta Edward P EP Lillard James W JW Singh Rajesh R
Cells 20200827 9
An abnormality in hedgehog (Hh) signaling has been implicated in the progression of prostate cancer (PCa) to a more aggressive and therapy-resistant disease. Our assessments of human PCa tissues have shown an overexpression of the Hh pathway molecules, glioma-associated oncogene homolog 1 (GLI-1), and sonic hedgehog (SHH). The effect of the natural compound thymoquinone (TQ) in controlling the expression of Hh signaling molecules in PCa was investigated in this study. We generated planetary ball ...[more]