Ontology highlight
ABSTRACT:
SUBMITTER: Albinana V
PROVIDER: S-EPMC7563408 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Albiñana Virginia V Gallardo-Vara Eunate E de Rojas-P Isabel I Recio-Poveda Lucia L Aguado Tania T Canto-Cano Ana A Aguirre Daniel T DT Serra Marcelo M MM González-Peramato Pilar P Martínez-Piñeiro Luis L Cuesta Angel M AM Botella Luisa Maria LM
Journal of clinical medicine 20200825 9
Von Hippel-Lindau (VHL), is a rare autosomal dominant inherited cancer in which the lack of VHL protein triggers the development of multisystemic tumors such us retinal hemangioblastomas (HB), CNS-HB, and clear cell renal cell carcinoma (ccRCC). ccRCC ranks third in terms of incidence and first in cause of death. Standard systemic therapies for VHL-ccRCC have shown limited response, with recurrent surgeries being the only effective treatment. Targeting of β2-adrenergic receptor (ADRB) has shown ...[more]