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Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning.

ABSTRACT: Modern drug discovery through de novo drug discovery entails high financial costs, low success rates, and lengthy trial periods. Drug repositioning presents a suitable approach for overcoming these issues by re-evaluating biological targets and modes of action of approved drugs. Coupling high-throughput technologies with genome-wide essentiality screens, network analysis, genome-scale metabolic modeling, and machine learning techniques enables the proposal of new drug-target signatures and uncovers unanticipated modes of action for available drugs. Here, we discuss the current issues associated with drug repositioning in light of curated high-throughput multi-omic databases, genome-wide screening technologies, and their application in systems biology/medicine approaches.

SUBMITTER: Mohammadi E

PROVIDER: S-EPMC7563533 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning.

Mohammadi Elyas E Benfeitas Rui R Turkez Hasan H Boren Jan J Nielsen Jens J Uhlen Mathias M Mardinoglu Adil A

Cancers 20200921 9

Modern drug discovery through de novo drug discovery entails high financial costs, low success rates, and lengthy trial periods. Drug repositioning presents a suitable approach for overcoming these issues by re-evaluating biological targets and modes of action of approved drugs. Coupling high-throughput technologies with genome-wide essentiality screens, network analysis, genome-scale metabolic modeling, and machine learning techniques enables the proposal of new drug-target signatures and uncov ...[more]

PMID: 32967266

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