Ontology highlight
ABSTRACT:
SUBMITTER: Romaniello D
PROVIDER: S-EPMC7563838 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Romaniello Donatella D Marrocco Ilaria I Belugali Nataraj Nishanth N Ferrer Irene I Drago-Garcia Diana D Vaknin Itay I Oren Roni R Lindzen Moshit M Ghosh Soma S Kreitman Matthew M Kittel Jeanette Clarissa JC Gaborit Nadege N Bergado Baez Gretchen G Sanchez Belinda B Eilam Raya R Pikarsky Eli E Paz-Ares Luis L Yarden Yosef Y
Cancers 20200824 9
Although two growth factor receptors, EGFR and HER2, are amongst the best targets for cancer treatment, no agents targeting HER3, their kinase-defective family member, have so far been approved. Because emergence of resistance of lung tumors to EGFR kinase inhibitors (EGFRi) associates with compensatory up-regulation of HER3 and several secreted forms, we anticipated that blocking HER3 would prevent resistance. As demonstrated herein, a neutralizing anti-HER3 antibody we generated can clear HER3 ...[more]