Oral and Fecal Microbiota in Lynch Syndrome.
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ABSTRACT:
SUBMITTER: Ferrarese R
PROVIDER: S-EPMC7563889 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Oral and Fecal Microbiota in Lynch Syndrome.
Ferrarese Roberto R Zuppardo Raffaella Alessia RA Puzzono Marta M Mannucci Alessandro A Amato Virginia V Ditonno Ilaria I Patricelli Maria Grazia MG Raucci Annalisa Russo AR Clementi Massimo M Elmore Ugo U Rosati Riccardo R Testoni Pier Alberto PA Mancini Nicasio N Cavestro Giulia Martina GM
Journal of clinical medicine 20200824 9
<h4>Background</h4>The role of microbiota in Lynch syndrome (LS) is still under debate. We compared oral and fecal microbiota of LS saliva and stool samples with normal healthy controls (NHC).<h4>Methods</h4>Total DNA was purified from feces and saliva to amplify the V3-V4 region of the 16s rRNA gene. Sequences with a high-quality score and length >250 bp were used for taxonomic analysis with QIIME software.<h4>Results</h4>Compared to NHC, LS fecal samples demonstrated a statistically significan ...[more]
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