Ontology highlight
ABSTRACT:
SUBMITTER: Arolt C
PROVIDER: S-EPMC7564650 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Arolt Christoph C Meyer Moritz M Hoffmann Franziska F Wagener-Ryczek Svenja S Schwarz David D Nachtsheim Lisa L Beutner Dirk D Odenthal Margarete M Guntinas-Lichius Orlando O Buettner Reinhard R von Eggeling Ferdinand F Klußmann Jens Peter JP Quaas Alexander A
Cancers 20200831 9
The composition of the extracellular matrix (ECM) plays a pivotal role in tumour initiation, metastasis and therapy resistance. Until now, the ECM composition of salivary gland carcinomas (SGC) has not been studied. We quantitatively analysed the mRNA of 28 ECM-related genes of 34 adenoid cystic (AdCy; <i>n</i> = 11), mucoepidermoid (MuEp; <i>n</i> = 14) and salivary duct carcinomas (SaDu; <i>n</i> = 9). An incremental overexpression of six collagens (including <i>COL11A1</i>) and four glycoprot ...[more]