Ontology highlight
ABSTRACT:
SUBMITTER: Mizuno K
PROVIDER: S-EPMC7564711 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Mizuno Keiko K Tanigawa Kengo K Nohata Nijiro N Misono Shunsuke S Okada Reona R Asai Shunichi S Moriya Shogo S Suetsugu Takayuki T Inoue Hiromasa H Seki Naohiko N
Cells 20200911 9
Lung adenocarcinoma (LUAD) is the most aggressive cancer and the prognosis of these patients is unfavorable. We revealed that the expression levels of both strands of <i>miR-99a</i> (<i>miR-99a-5p</i> and <i>miR-99a-3p</i>) were significantly suppressed in several cancer tissues. Analyses of large The Cancer Genome Atlas (TCGA) datasets showed that reduced <i>miR-99a-5p</i> or <i>miR-99a-3p</i> expression is associated with worse prognoses in LUAD patients (disease-free survival (DFS): <i>p</i> ...[more]