Ontology highlight
ABSTRACT:
SUBMITTER: Yan K
PROVIDER: S-EPMC7564786 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Yan Kexin K Vet Laura J LJ Tang Bing B Hobson-Peters Jody J Rawle Daniel J DJ Le Thuy T TT Larcher Thibaut T Hall Roy A RA Suhrbier Andreas A
Vaccines 20200709 3
Despite the availability of an effective, live attenuated yellow fever virus (YFV) vaccine (YFV 17D), this flavivirus still causes up to ≈60,000 deaths annually. A number of new approaches are seeking to address vaccine supply issues and improve safety for the immunocompromised vaccine recipients. Herein we describe an adult female IFNAR-/- mouse model of YFV 17D infection and disease that recapitulates many features of infection and disease in humans. We used this model to evaluate a new YFV va ...[more]