Ontology highlight
ABSTRACT:
SUBMITTER: Pasco ST
PROVIDER: S-EPMC7564904 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Cells 20200916 9
Vaccine design traditionally focuses on inducing adaptive immune responses against a sole target pathogen. Considering that many microbes evade innate immune mechanisms to initiate infection, and in light of the discovery of epigenetically mediated innate immune training, the paradigm of vaccine design has the potential to change. The Bacillus Calmette-Guérin (BCG) vaccine induces some level of protection against Mycobacterium tuberculosis (Mtb) while stimulating trained immunity that correlates ...[more]