Atypical Membrane-Anchored Cytokine MIF in a Marine Dinoflagellate.
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ABSTRACT:
SUBMITTER: Jaouannet M
PROVIDER: S-EPMC7565538 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Atypical Membrane-Anchored Cytokine MIF in a Marine Dinoflagellate.
Jaouannet Maëlle M Pavaux Anne-Sophie AS Pagnotta Sophie S Pierre Olivier O Michelet Claire C Marro Sophie S Keller Harald H Lemée Rodolphe R Coustau Christine C
Microorganisms 20200820 9
Macrophage Migration Inhibitory Factors (MIF) are pivotal cytokines/chemokines for vertebrate immune systems. MIFs are typically soluble single-domain proteins that are conserved across plant, fungal, protist, and metazoan kingdoms, but their functions have not been determined in most phylogenetic groups. Here, we describe an atypical multidomain MIF protein. The marine dinoflagellate <i>Lingulodinium polyedra</i> produces a transmembrane protein with an extra-cytoplasmic MIF domain, which local ...[more]
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