Unknown

Dataset Information

0

Pharmacological Effects of Agastache rugosa against Gastritis Using a Network Pharmacology Approach.


ABSTRACT: Agastache rugosa is used as a Korean traditional medicine to treat gastric diseases. However, the active ingredients and pharmacological targets of A. rugosa are unknown. In this study, we aimed to reveal the pharmacological effects of A. rugosa on gastritis by combining a mice model and a network pharmacology method. The macrophage and gastritis-induced models were used to evaluate the pharmacological effects of A. rugosa. The results show that A. rugosa relieved mucosal damage induced by HCl/EtOH in vivo. Network analysis identified 99 components in A. rugosa; six components were selected through systematic screening, and five components were linked to 45 gastritis-related genes. The main components were acacetin and luteolin, and the identified core genes were AKT serine/threonine kinase 1 (AKT1), nuclear factor kappa B inhibitor alpha (NFKBIA), and mitogen-activated protein kinase-3 (MAPK3) etc. in this network. The network of components, target genes, protein-protein interactions, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway was closely connected with chemokines and with phosphoinositide 3-kinase-Akt (PI3K/AKT), tumor-necrosis-factor alpha (TNF?), mitogen-activated protein kinase, nuclear factor kappa B, and Toll-like receptor (TLR) pathways. In conclusion, A. rugosa exerts gastro-protective effects through a multi-compound and multi-pathway regulatory network and holds potential for treating inflammatory gastric diseases.

SUBMITTER: Nam HH 

PROVIDER: S-EPMC7565599 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Pharmacological Effects of <i>Agastache rugosa</i> against Gastritis Using a Network Pharmacology Approach.

Nam Hyeon-Hwa HH   Kim Joong Sun JS   Lee Jun J   Seo Young Hye YH   Kim Hyo Seon HS   Ryu Seung Mok SM   Choi Goya G   Moon Byeong Cheol BC   Lee A Yeong AY  

Biomolecules 20200909 9


<i>Agastache rugosa</i> is used as a Korean traditional medicine to treat gastric diseases. However, the active ingredients and pharmacological targets of <i>A. rugosa</i> are unknown. In this study, we aimed to reveal the pharmacological effects of <i>A. rugosa</i> on gastritis by combining a mice model and a network pharmacology method. The macrophage and gastritis-induced models were used to evaluate the pharmacological effects of <i>A. rugosa</i>. The results show that <i>A. rugosa</i> relie  ...[more]

Similar Datasets

| S-EPMC4433173 | biostudies-literature
| S-EPMC3547811 | biostudies-literature
| S-EPMC7555585 | biostudies-literature
| S-EPMC7048923 | biostudies-literature