Ontology highlight
ABSTRACT:
SUBMITTER: Osu N
PROVIDER: S-EPMC7565683 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Journal of personalized medicine 20200725 3
Carbon-ion radiotherapy (CIRT) has strong antitumor effects and excellent dose conformity. In head-and-neck squamous cell carcinoma (HNSCC), human papillomavirus (HPV) status is a prognostic factor for photon radiotherapy outcomes. However, the effect of HPV status on the sensitivity of HNSCCs to carbon ions remains unclear. Here, we showed that the relative biological effectiveness (RBE) of carbon ions over X-rays was higher in HPV-negative cells than in HSGc-C5 cells, which are used for CIRT d ...[more]