Resting-state functional connectivity in early postanaesthesia recovery is characterised by globally reduced anticorrelations.

ABSTRACT:

Background

A growing body of literature addresses the possible long-term cognitive effects of anaesthetics, but no study has delineated the normal trajectory of neural recovery attributable to anaesthesia alone in adults. We obtained resting-state functional MRI scans on 72 healthy human volunteers between ages 40 and 80 (median: 59) yr before, during, and after general anaesthesia with sevoflurane, in the absence of surgery, as part of a larger study on cognitive function postanaesthesia.

Methods

Region-of-interest analysis, independent component analysis, and seed-to-voxel analysis were used to characterise resting-state functional connectivity and to differentiate between correlated and anticorrelated connectivity before, during, and after general anaesthesia.

Results<

SUBMITTER: Nir T 

PROVIDER: S-EPMC7565909 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature